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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: special study

Data source

Reference
Reference Type:
publication
Title:
The in vitro effects of selcted environmental toxicants on two heme synthesis enzymes
Author:
Johnson DJ, Williams HL, Slater S, Haut MJ, Altstatt LB
Year:
1985
Bibliographic source:
J Environ Pathol Toxicol Oncol 6, 211-218

Materials and methods

Type of study / information:
haemotoxicity in vitro
Principles of method if other than guideline:
The effect of p-chlorotoluene on heme synthesis in vitro was examined by studying the influence of tis compound on delta-amino/evulinic acid synthetase (ALAS) and ferrochelatase (FC) activities in rat liver homogenates.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorotoluene
EC Number:
203-397-0
EC Name:
4-chlorotoluene
Cas Number:
106-43-4
Molecular formula:
C7H7Cl
IUPAC Name:
4-chlorotoluene
Details on test material:
p-chlorotoluene ws purchased from the Aldrich Chemical company, Milwaukee, WI 53233

Results and discussion

Applicant's summary and conclusion

Executive summary:
The effect of p-chlorotoluene on heme synthesis in vitro was determined by studying its influence on delta-amino-levulinic acid synthetase (ALAS) and ferrochelatase (FC)activities in rat liver homogenates; at a final concentration of 0.001 mol/l (= 126 ug/ml), p-chlorotoluene induced a very slight inhibition of ALAS activity (activity, expressed as percentage of control: 97 %), whereas the activity of FC remained unaffected by p-chlorotoluene.