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EC number: 203-397-0 | CAS number: 106-43-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: in compliance with guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FDA guideline, Vol 38, no 187 (1973)
- Principles of method if other than guideline:
- 6 rabbits with shaved flancs (each site with intact and scarificed areas) received gauze patches containing 0.5 ml undiluted testsubstance (right flanc) or a 10 % sesame oil solution (left flanc) fixed with a tape and PVC foil (occlussive dressing) for 24 hours. Reading was done immediately after removal of the dressing (24 hour value) and 48 hrs and 72 hrs after start of the experiment. Evaluation of the findings according to Federal Register 38,No.187,1973, § 1500.41
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorotoluene
- EC Number:
- 203-397-0
- EC Name:
- 4-chlorotoluene
- Cas Number:
- 106-43-4
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 4-chlorotoluene
- Details on test material:
- p-chlorotoluene (no data on purity)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: sesame oil
- Controls:
- not required
- Amount / concentration applied:
- other: see freetext ME
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 24, 48, and 72 hours
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0.21
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 3 days
- Remarks on result:
- other: undilited test substance - intact and scarificed skin
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 2 days
- Remarks on result:
- other: 10% solution of the test substance - intact and scarificed skin
- Other effects:
- no data
Any other information on results incl. tables
undiluted testsubstance:
----intact area, reading:
24 hrs: 2/6 with edema, score 1 of max 4; no erythema
48 hrs: 1/6 with edema, score 1 of max 4; no erythema
72 hrs: 0/6 with edema; no erythema
----scarificed area, reading:
24 hrs: 3/6 with edema, score 1 of max 4; no erythema
48 hrs: 0/6 with edema; no erythema
72 hrs: 0/6 with edema; no erythema
irritation index (24 and 72 hours): 0.21 of max 8.0
10% sesame oil solution:
-----intact area, reading:
24 hrs: 1/6 with edema, score 1 of max 3, no erythema
48 hrs: 0/6 with edema, no erythema
72 hrs: 0/6 with edema, no erythema
-----scarificed area
24 hrs: 0/6 with edema, no erythema
48 hrs: 0/6 with edema, no erythema
72 hrs: 0/6 with edema, no erythema
irritation index (24 and 72 hours): 0.04 of max 8.0
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
method: 6 rabbits with shaved flancs (each site with intact and scarificed areas) received gauze patches containing 0.5 ml undiluted testsubstance (right flanc) or a 10 % sesame oil solution (left flanc) fixed with a tape and PVC foil (occlussive dressing) for 24 hours. Reading was done immediately after removal of the dressing (24 hour value) and 48 hrs and 72 hrs after start of the experiment. Evaluation of the findings according to Federal Register 38,No.187,1973, § 1500.41
result: not irritating to the skin (intact and scarificed skin)
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