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EC number: 203-397-0 | CAS number: 106-43-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature - comparable to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- Principles of method if other than guideline:
- On each of days 6 to 19 inclusive on preganancy 25 animals were transferred to exposure chambers and exposed to a an atmosphere of the test material at concnetrations of 0, 1, 3, or 9 mg/litre air for 6 hours. All animals were killed on day 20 of preganancy, dissected and examined for abnormalities and changes in maternal organs. The ovaries and uteri were examined to determine number of corpora lutea, number of distribution of live young, number and ditribution of embryonic/foetal deaths, individual foetal weight, gross foetal abnormalities. half of the pups in each litter were preserved for subsequent sectioning to discover visceral abnormalities; the remainder were fixed for skeletal examination.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-chlorotoluene
- EC Number:
- 202-424-3
- EC Name:
- 2-chlorotoluene
- Cas Number:
- 95-49-8
- Molecular formula:
- C7H7Cl
- IUPAC Name:
- 1-chloro-2-methylbenzene
- Details on test material:
- purity: 96.5 % o-chlorotoluene, 3.4 % p-chlorotoluene, 0.1 % toluene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CrL : COBS CD (SD) BR
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- yes
- Details on mating procedure:
- not applicable
- Duration of treatment / exposure:
- days 6-19 of gestation
- Frequency of treatment:
- 6 h/d
- Duration of test:
- days 6-19 of gestation
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1.1, 3.1 or 9.0 mg/l
Basis:
analytical conc.
- No. of animals per sex per dose:
- 25
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Sex: female
Duration of test: on day 20 of gestation the dams were killed
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEC
- Effect level:
- 1.1 mg/L air
- Basis for effect level:
- other: maternal toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:yes
Effect levels (fetuses)
- Dose descriptor:
- NOAEC
- Effect level:
- 3.1 mg/L air
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
1.1 mg/l:
no maternal effects being obviously attributable to treatment
fetal effects: 4 malformed fetus compared to 3 in the control group. One showing brachygnathia, one showing retro-oesophageal aortic arch, one showing cardiac ventricular septal defect and one showing brachydactyly and bachymelia of all four limbs. The last malformation was similiar with the observed malformation of six fetuses at 9 mg/l
3.1 mg/l: maternal effects: slight ataxia observable during the exposure periods
fetal effects: no notable or significant deviations from control values among litter parameters and among indices of malformations, anomalies and skeletal variants of the offspring
3.1 and 9 mg/l: maternal effects: dosage-related reduction in food consumption and in bodyweight gain and dosage-related increase in water consumption
9 mg/l: maternal effects: ataxia, lachrymation and/or salivation among occasional animals during exposure, and brown
fur staining;
fetal effects: mean values for litter and mean fetal weight
significantly reduced; increase in the incidence of fetal
malformations mainly due to the occurrence of six fetuses
(distributed among four litters) showing brachydactyly of a
single fore- or hindpaw; for five of the 6 fetuses the
brachydactyly was associated with a terminal haemorrhagic
area on the affected paw; 3 other malformations (1 microphthalmia,1 anophthalmia amd 1 cardiac ventricular septal defect); correlating with the lower mean fetal weight, reduced skeletal ossification observable,
providing an increased incidence of fetuses with sternebral variants and contributing to a significant increase in fetuses with skeletal anomaly; incidence of visceral anomalies unaffected
Applicant's summary and conclusion
- Executive summary:
On each of days 6 to 19 inclusive on preganancy 25 animals were transferred to exposure chambers and exposed to a an atmosphere of the test material at concnetrations of 0, 1, 3, or 9 mg/litre air for 6 hours. All animals were killed on day 20 of preganancy, dissected and examined for abnormalities and changes in maternal organs. The ovaries and uteri were examined to determine number of corpora lutea, number of distribution of live young, number and ditribution of embryonic/foetal deaths, individual foetal weight, gross foetal abnormalities. half of the pups in each litter were preserved for subsequent sectioning to discover visceral abnormalities; the remainder were fixed for skeletal examination.
The NOAEL for maternal toxicity is 1.1 mg/litre, the NOAEL for teratogenicity is 3.1 mg/litre.
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