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Registration Dossier
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EC number: 247-851-6 | CAS number: 26619-69-2
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2014 - October 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- [1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
- EC Number:
- 247-851-6
- EC Name:
- [1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
- Cas Number:
- 26619-69-2
- Molecular formula:
- C15H24O
- IUPAC Name:
- [1aR-(1aα,4aα,7α,8aS*)]-octahydro-4,4,8,8-tetramethyl-4a,7-methano-4aH-naphth[1,8a-b]oxirene
- Reference substance name:
- 7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol
- Cas Number:
- 29461-20-9
- Molecular formula:
- C15H24O
- IUPAC Name:
- 7,7,8,8-tetramethyloctahydro-2,3b-methanocyclopenta[1,3]cyclopropa[1,2]benzen-4-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in the expert statement): Folenox
- Chemical name: 4,4,8,8-Tetramethyloctahydro-4a,7-methanonaphtho[1,8a-b]oxirene (IUPAC)
- Empirical formula: C15H24O
- Structural formula: See IUCLID section 1
Constituent 1
impurity 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Buffers:
- Acetate buffer pH 4, 0.01 M
Phosphate buffer pH 7, 0.01 M
Borate buffer pH 9, 0.01 M
Duration of testopen allclose all
- Duration:
- 0.33 h
- pH:
- 4
- Temp.:
- 20 °C
- Initial conc. measured:
- 0.994 mg/L
- Duration:
- 148.8 h
- pH:
- 7
- Temp.:
- 20 °C
- Initial conc. measured:
- 1.46 mg/L
- Duration:
- 23.53 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.54 mg/L
- Duration:
- 5.67 h
- pH:
- 7
- Temp.:
- 60 °C
- Initial conc. measured:
- 1.47 mg/L
- Duration:
- 720 h
- pH:
- 9
- Temp.:
- 20 °C
- Initial conc. measured:
- 1.42 mg/L
- Duration:
- 221.27 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.85 mg/L
Results and discussion
- Transformation products:
- not measured
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- 2.7 min
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 38 h
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 56 d
- Details on results:
- At pH7 and pH9, the half-life times at temperartures of 50 and 60 were also determined. See attached study report for details.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Executive summary:
The rate of hydrolysis of Folenox as a function of pH was determined at pH values normally found in the environment (pH 4 to 9). The results indicate that Folenox does undergo hydrolysis. Folenox undergoes faster hydrolysis in acidic conditions (pH 4), and slower hydrolysis in alkaline conditions (pH 9). The half-life times of the test substance at 20'C were determined to be 2.7 minutes (pH 4), 38 hours (pH 7) and 56 days (pH 9).
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