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Diss Factsheets
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EC number: 247-851-6 | CAS number: 26619-69-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- December, 1969 - February, 1970
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Not a validated method for determining skin irritation or skin sensitisation, but provides reliable supporting information for “in-use” concentrations using a “standard practice” applied to ingredients for consumer formulations. As only 2% is tested, no conclusion can be drawn for the 100% substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The method followed in this study was that of the repeated insult method approved by the Food and Drug Administration and known as the Draize technique.
- GLP compliance:
- no
- Remarks:
- not present at the time of performance.
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Giv 2-3907 Folenox
- Chemical name: Isolongifolene Epoxide
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - 16 males and 38 females volunteers (62 were treated, 8 dropped)
- ages varied from 18 to 70 years
- No person was accepted with active dermatologic conditions or other descernible illness - Clinical history:
- No data
- Route of administration:
- dermal
- Details on study design:
- PRE-TEST:
In a pilot group with 10 subjects, the test material was applied in closed patch test to the inner surface of the left deltoid area. 48 hours later, the patch was removed and the reading was recorded. When no objective manifestations of irritation developed after the reading, the full sensitization study was planned.
MAIN STUDY:
The procedure consists in the repeated application cyclicly closed patch tests with 0.5 mL of test solution being applied to individual absorbent patch.The patch was then applied to the area to be tested in a definite fixed sequence. The patch was then secured by means of overlying strips of impervious adhesive tape which was then further occluded with additional overlying strips of similar tape. The patch was allowed to remain in situ for 48 hours and then removed, at which readings were recorded.
The initial site of application of the patch was the inner surface of the right deltoid area. When it was removed 48 hours after application, the next application was made to the inner surface of the left deltoid area. The third application was made to the original site of the first application, the inner surface of the right deltoid area, and the fourth application was made to the site of the second application on the medial surface of the left deltoid area. Thus the cycle of rotation of the sites of application was alternately between the inner surfaces of the right and left deltoid areas for a total of ten applications. The concluding challenge tests were applied in precise duplicates to the inner surface of each deltoid area, 2 weeks after the induction fase finished for 48 hours.
Results and discussion
- Results of examinations:
- The 54 subjects demonstrated responses during the induction series. These responses varied from a plus minus reaction to a plus one reponse. Because all these reactions were of very mild type, because none of them were repeated in any individual, and because the challenge tests produced no reactions, one must assume that these reactions are neither irritative nor allergic in origin.
Any other information on results incl. tables
Other effects: Adhesive tape reactions occurred.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of a repeated occlusive patch test procedure, the 2% test material Folenox produced one very mild reaction during the induction phase. The challenge phase produced no reactions. No conclusions can de drawn on the 100% test substance.
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