Registration Dossier
Registration Dossier
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EC number: 231-154-9 | CAS number: 7440-45-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
No reproductive studies were conducted specifically on cerium metal, but on other soluble cerium-compounds which were used for read-across. Due to the low water solubility of cerium metal as compared to the cerium carbonate, the resulting read-across is a conservative estimate (see read-across approach).
The results from the key study on cerium carbonate showed a NOAEL for reproductive performance (mating and fertility) of 1000 mg/kg/day, a NOAEL for toxic effects on progeny of 1000 mg/kg/day and the absence of results in the examination of the parental and offspring animals. Therefore, it is not expected that cerium metal is a reproductive toxicant.
Short description of key information:
It is not expected that cerium metal is a reproductive toxicant.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Dose descriptor:
- LOAEL
- 80 mg/kg bw/day
Additional information
No reproductive studies were conducted specifically on cerium metal, but on other soluble cerium-compounds which were used for read-across. Due to the low water solubility of cerium metal as compared to the cerium citrate, the resulting read-across is a conservative estimate (see read-across approach).
The results from the key study on cerium citrate showed a LOAEL for developmental toxicity of 80 mg/kg/day. These results suggest that cerium is of relatively low toxicity to the developing organism.
Justification for classification or non-classification
It is not expected that cerium metal is a reproductive or developmental toxicant and therefore classification is not warranted.
Additional information
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