Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-154-9 | CAS number: 7440-45-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
No reproductive studies were conducted specifically on cerium metal, but on other soluble cerium-compounds which were used for read-across. Due to the low water solubility of cerium metal as compared to the cerium carbonate, the resulting read-across is a conservative estimate (see read-across approach).
The results from the key study on cerium carbonate showed a NOAEL for reproductive performance (mating and fertility) of 1000 mg/kg/day, a NOAEL for toxic effects on progeny of 1000 mg/kg/day and the absence of results in the examination of the parental and offspring animals. Therefore, it is not expected that cerium metal is a reproductive toxicant.
Short description of key information:
It is not expected that cerium metal is a reproductive toxicant.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Dose descriptor:
- LOAEL
- 80 mg/kg bw/day
Additional information
No reproductive studies were conducted specifically on cerium metal, but on other soluble cerium-compounds which were used for read-across. Due to the low water solubility of cerium metal as compared to the cerium citrate, the resulting read-across is a conservative estimate (see read-across approach).
The results from the key study on cerium citrate showed a LOAEL for developmental toxicity of 80 mg/kg/day. These results suggest that cerium is of relatively low toxicity to the developing organism.
Justification for classification or non-classification
It is not expected that cerium metal is a reproductive or developmental toxicant and therefore classification is not warranted.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
