Registration Dossier
Registration Dossier
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EC number: 200-752-1 | CAS number: 71-41-0
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- For justification of read across please refer to section 13.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII
- Author:
- Smyth Jr. HF et al.
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal (AIHAJ), 30(5), 470-476
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 008
- Bibliographic source:
- RIFM database
Materials and methods
- Principles of method if other than guideline:
- acc. to Smyth HF et al. (1962). Range-Finding Toxicity Data: List VI. Am. Ind. Hyg. Assoc. J. 23: 95-107
- GLP compliance:
- no
- Test type:
- other: inhalation hazard test
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methylbutan-1-ol
- EC Number:
- 204-633-5
- EC Name:
- 3-methylbutan-1-ol
- Cas Number:
- 123-51-3
- Molecular formula:
- C5H12O
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 3-Methyl-1-butanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: room air
- System of generating particulates/aerosols: The test material (50 - 100 grams) was spread over a shallow tray which was placed in a 120-liter sealed chamber for a minimum of 24 hours - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- concentrated vapour
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 10 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: calculated acc. to formula: vapour saturation (mg/l) = 0.0412 * vapour pressure (hPa) * molecular weight (g/mol); Inhalation hazard test
- Mortality:
- No mortality within the 14 day observation period after exposure of 8 h.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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