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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

Type of composition:
boundary composition of the substance
State / form:
solid: particulate/powder
Reference substance:
PBT status:
the substance is not PBT / vPvB

L-4-Hydroxyproline was determined to be rapidly biodegradable.

Bioaccumulation of L-4-Hydroxyproline can be excluded due the low log Kow of -3.17.

L-4-Hydroxyproline is not classified as carcinogenic, mutagenic, toxic for reproduction or Specific Target Organ Toxicity after repeated exposure according to Regulation EC No. 1272/2008 (CLP).

L-4-Hydroxyproline was determined to be not toxic to the aquatic environment according to Regulation EC No. 1272/2008 (CLP).