Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

An experimental key study and a study based upon calculation indicate that L-4-hydroxyproline is readily biodegradable. Therefore, L-4-hydroxyproline is readily biodegradable. In accordance with REACH Annex VIII No. column 2, the study on hydrolysis does not need to be conducted if the substance is readily biodegradable.

In accordance with REACH Annex VIII section 9.3.1. column 2 as well as REACH Annex IX section 9.3.3. column 2 the study on adsorption/desorption screening (required in section 9.3.1. column 1) does not need to be conducted as the substance has a low log Kow as well as the substance and its degradation products decompose rapidly. Adsorption to solid soil phase is not expected. L-4-hydroyproline will not evaporate into the atmosphere from the water surface.

Additional information