Registration Dossier

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

An experimental key study and a study based upon calculation indicate that L-4-hydroxyproline is readily biodegradable. Therefore, L-4-hydroxyproline is readily biodegradable. In accordance with REACH Annex VIII No. 9.2.2.1 column 2, the study on hydrolysis does not need to be conducted if the substance is readily biodegradable.


In accordance with REACH Annex VIII section 9.3.1. column 2 as well as REACH Annex IX section 9.3.3. column 2 the study on adsorption/desorption screening (required in section 9.3.1. column 1) does not need to be conducted as the substance has a low log Kow as well as the substance and its degradation products decompose rapidly. Adsorption to solid soil phase is not expected. L-4-hydroyproline will not evaporate into the atmosphere from the water surface.

Additional information