Registration Dossier
Registration Dossier
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EC number: 500-247-9 | CAS number: 72009-86-0 1 - 2.5 moles ethoxylated
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
No toxicokinetic data (absorption, metabolism and elimination) is available on either the target substance or the source substance.
As no specific data for the absorption rate from the oral, the dermal or the inhalational route of exposure is available, default assumptions will be applied. Thus, absorption from the dermal and the oral route is considered to be the same. For extrapolation from oral exposure to inhalation exposure the absorption by inhalation is assumed to be a factor 2 higher.
Non-specific esterase activity in the gastrointestinal tract(including from gastrointestinal microorganisms) and in liver and plasma may result in hydrolysis of the target substance into 2-(2-biphenylyloxy)ethanol + acrylic acid and for the source substance into 2-phenoxyethanol + acrylic acid. No specific data as to the extent and rate of this type of metabolism is available but it may be anticipated that the unspecific esterase activity may be rather similar for the target as well as for the source substance.
see also read-across justification in section 13
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Based on a read-across approach from data on 2 -phenoxyethyl acrylate to Biphenyl-2-ol, ethoxylated, esters with acrylic acid no/low bioaccumulation is expected.
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