Biphenyl-2-ol, ethoxylated, esters with acrylic acid

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Standard draize test with no deviations reported

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Draize: Appraisal of the safety of chemicals in foods, drugs and cosmetics. In Dermal toxicity p. 46-59 1959

Principles of method if other than guideline:

The eye irritation potential was test as described by Draize; Appraisal of the safety of chemicals in foods, drugs and cosmetics. In dermal toxicity p. 46 -59, 1959: Austin, Tex: Association of food and drug officials of the united states.
The substance was applied to one eye, and irritation score was measured after 1 hour, 24 hours, 48 hours 72 hours and 8 days.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethyl acrylate

EC Number:

256-360-6

EC Name:

2-phenoxyethyl acrylate

Cas Number:

48145-04-6

Molecular formula:

C11H12O3

IUPAC Name:

2-phenoxyethyl prop-2-enoate

Test material form:

liquid: viscous

Details on test material:

SR 339 C, Lot number HZI 1511, clear liquid.

Test animals / tissue source

Species:

rabbit

Strain:

Vienna White

Details on test animals or tissues and environmental conditions:

Animals were kept in steel cages, one animal per cage. 20-26C, relative humidity; 30-70%. 12:12 light:dark cycle, light from 0600 to 1800.

Test system

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.1 ml undiluted

Duration of treatment / exposure:

The substance was applied once, and not washed off

Observation period (in vivo):

1 hour, 24 hours, 48 hours, 72 hours and 8 days.

Number of animals or in vitro replicates:

6 animals

Details on study design:

Untreated eye served as control

Results and discussion

In vivo

Results

Irritation parameter:

conjunctivae score

Basis:

mean

Time point:

other: 24 hours

Score:

ca. 1

Max. score:

1

Reversibility:

fully reversible

Irritant / corrosive response data:

After 24 hours no effects were observed in stratum corneum, or iris. All six animals showed light increased redness in conjuctival tissue, without swelling, but two animals showed light secretion. After 48 hours only one animal showed increased redness in conjuctival tissue, no other effetcs were observed. no effects were seen at later time points, the eye irritation effects were therefore fully reversible.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information Criteria used for interpretation of results: US CPSC / US FDA

Conclusions:

2-phenoxyethyl acrylate is slightly irritating to the rabbits eye when applied undiluted. The irritating effect were observed as slightly increased redness of conjuctival tissue, and the effect were fully reversible within 48 hours.

Executive summary:

The eye irritation potential of 2 -phenoxyethyl acrylate were investigated in rabbits following the draize test. The substance was shown to be slightly irritating, but fully reversible after 48 hours.