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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data iis from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw material monograph for Black Pepper Oil
Author:
D.L.J Opdyke
Year:
1963
Bibliographic source:
Food and Cosmetics Toxicology. V.19, 1963

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate skin irritation potential of Black Pepper Oil on back of hairless mice.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Essential Oil of Piper nigrum L. (Family: Piperaceae). Obtained by the steam distillation of dried unripe berries.
EC Number:
616-894-6
Cas Number:
8006-82-4
IUPAC Name:
Essential Oil of Piper nigrum L. (Family: Piperaceae). Obtained by the steam distillation of dried unripe berries.
Test material form:
liquid - liquid: emulsion
Details on test material:
- Name of test material: Black Pepper Oil
- IUPAC name: Pepper, black, oil (Piper nigrum L.)
- Molecular formula: Unspecified
- Molecular weight: Unspecified
- Smiles : Unspecified
- Inchl: Unspecified
- Substance type: Organic
- Physical state: Liquid (colorless to slightly greenish)
Specific details on test material used for the study:
- Name of test material: Black Pepper Oil
- IUPAC name: Pepper, black, oil (Piper nigrum L.)
- Molecular formula: Unspecified
- Molecular weight: Unspecified
- Smiles : Unspecified
- Inchl: Unspecified
- Substance type: Organic
- Physical state: Liquid (colorless to slightly greenish)

Test animals

Species:
mouse
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Not specified
Duration of treatment / exposure:
24 hrs
Observation period:
24 hrs
Number of animals:
Not specified
Details on study design:
Not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No positive skin reaction were observed

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
Black pepper oil when applied on the back of hairless mice in undiluted form for 24 hrs showed no skin reactions. Hence , Black pepper oil was considered to be not irritating to the skin of mice.
Executive summary:

Black pepper oil was used as a test material to evaluate its skin irritation potential. Black pepper oil when applied on the back of hairless mice in undiluted for 24 hrs showed no skin reactions. Hence , Black pepper oil was considered to be not irritating to the skin of mice.