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Administrative data

Endpoint:
thermal stability
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 - 20 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 113 (Screening Test for Thermal Stability and Stability in Air)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium 2-oxoglutarate
EC Number:
206-167-8
EC Name:
Disodium 2-oxoglutarate
Cas Number:
305-72-6
Molecular formula:
C5H6O5.2Na
IUPAC Name:
disodium 2-oxopentanedioate
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
Test material form:
solid: crystalline
Remarks:
Crystalline powder
Details on test material:
Batch No: 14152300
Storage: 15 – 25 °C

Results and discussion

For thermal stability study

Test substance thermally stable:
yes
Operating temperatureopen allclose all
Key result
Operating temp.:
>= 180 - <= 240 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 240 - <= 270 °C
Remarks on result:
other: exothermic effect
Key result
Operating temp.:
>= 290 - <= 350 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 360 - <= 410 °C
Remarks on result:
other: endothermic effect
Key result
Operating temp.:
>= 410 - <= 460 °C
Remarks on result:
other: exothermic effect
Sublimation:
not determined
Transformation products:
not specified

Any other information on results incl. tables

In the temperature range of 180 – 240 °C a first small endothermic effect can be observed, directly followed by an exothermic effect in the temperature range of 240 – 270 °C, with an average decomposition energy of -70 J/g. Two further endothermic effects occurred in the temperature ranges of 290 – 350 °C and 360 – 410 °C, directly followed by a second exothermic effect in the temperature range of 410 – 460 °C, with an average decomposition energy of -60 J/g.

Applicant's summary and conclusion

Conclusions:
In a thermal stability test according to the OECD test guideline 113, the test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) showed two exothermic effects in the temperature ranges of 240 – 270 °C and 410 – 460 °C with an overall decomposition energy of approx. -130 J/g.
Executive summary:

In a thermal stability test according to the OECD test guideline 113, the test item Alpha-Ketoglutarate disodium salt (CAS no. 305 -72 -6) showed two exothermic effects in the temperature ranges of 240 – 270 °C and 410 – 460 °C with an overall decomposition energy of approx. -130 J/g.