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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15 March 2017 - 22 May 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
other: 2 effusion methods: Vapour pressure balance and Knudsen cell

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium 2-oxoglutarate
EC Number:
206-167-8
EC Name:
Disodium 2-oxoglutarate
Cas Number:
305-72-6
Molecular formula:
C5H6O5.2Na
IUPAC Name:
disodium 2-oxopentanedioate
impurity 1
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Oxidane
Test material form:
solid: crystalline
Remarks:
Crystalline powder
Details on test material:
Batch No: 14152300
Storage: 15 – 25 °C

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
< 0.02 Pa
Remarks on result:
other: calculated by extrapolation
Key result
Temp.:
25 °C
Vapour pressure:
< 0.02 Pa
Remarks on result:
other: calculated by extrapolation
Key result
Temp.:
50 °C
Vapour pressure:
< 0.02 Pa
Remarks on result:
other: calculated by extrapolation

Any other information on results incl. tables

Effusion method: Knudsen-Cell

The vapour pressure was determined for 13 temperatures in the temperature range of 20 – 130 °C. Due to the fact that the test item showed no proper linear correlation of the vapour pressure and the inverse temperature 1/T, the Antoine constants cannot be evaluated in the measured temperature range. Since no evaluable vapour pressure curve could be determined a further test series was performed using the vapour pressure balance.

 Vapour pressure balance:

With the vapour pressure balance method, the vapour pressure was determined for 14 temperatures in the temperature range of 37 – 163 °C. Due to the fact that the test item showed no proper linear correlation of the vapour pressure and the inverse temperature 1/T, the Antoine constants cannot be evaluated in the measured temperature range.

Due to the results of both effusion methods, the vapour pressures for the temperatures 20, 25 and 50 °C are estimated on the basis of the maximum measured vapourpressures of 2.01 × 10-2 Pa at temperatures of 153 °C.

Applicant's summary and conclusion

Conclusions:
The test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) showed no evaluable vapour pressure curve in the temperature range of 20 to 163 °C. Due to this result, the vapour pressures for the temperatures 20, 25 and 50 °C are estimated on the basis of the maximum vapour pressures measured by the vapour pressure balance, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006).
The vapour pressure of the test item was < 0.02 Pa at 20°C, 25°C and at 50°C.
Executive summary:

The test item Alpha-Ketoglutarate disodium salt (CAS no. 305-72-6) showed no evaluable vapour pressure curve in the temperature range of 20 to 163 °C. Due to this result, the vapour pressures for the temperatures 20, 25 and 50 °C are estimated on the basis of the maximum vapour pressures measured by the vapour pressure balance, according to Regulation EC No. 440/2008 Method A.4. Vapour Pressure and OECD Test Guideline 104 (2006).

The vapour pressure of the test item was < 0.02 Pa at 20°C,  25°C and at 50°C.