Registration Dossier
Registration Dossier
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EC number: 212-550-0 | CAS number: 825-90-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1972
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- refer chapter 13 for detailed read across justification
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 40% solution of the test substance was instilled in eyes and exposed eyes were observed for 72 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium xylenesulphonate
- EC Number:
- 215-090-9
- EC Name:
- Sodium xylenesulphonate
- Cas Number:
- 1300-72-7
- Molecular formula:
- C8H10O3S.Na
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- None
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- Albino rabbit
- Details on test animals or tissues and environmental conditions:
- None
Test system
- Vehicle:
- not specified
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 6 per dose
- Details on study design:
- 40 % aqueous solution; at pH 7.6 and 9.4
Results and discussion
In vivo
Results
- Irritation parameter:
- other: See 'remarks on results'
- Remarks on result:
- other: Considered a minimal irritant according to Federal Hazardous Substances Act regulations, Section 191.12.
- Irritant / corrosive response data:
- None
- Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Sodium xylenesulfonate was considered to be slightly irritating to the eyes of rabbits.
- Executive summary:
Sodium xylenesulfonate was evaluated for eye irritation potential in rabbits. 40 % aqueous solution of sodium xylenesulfonate 40 %; at pH 7.6 and 9.4 was used for this purpose. 6 albino rabbits per dose were exposed. Based on the outcome of the study, sodium xylenesulfonate was considered a minimal irritant according to Federal Hazardous Substances Act regulations, Section 191.12
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