Registration Dossier
Registration Dossier
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EC number: 212-550-0 | CAS number: 825-90-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 13 January, 2021
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
: OECD Toolbox
2. MODEL (incl. version number) : 4.4.1
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL : CAS number 890-25-1 was used.
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
The QMRF is attached in the section 13 with the title "Prediction of Skin sensitisation for Benzenesulfonic acid, 4-hydroxy-, monosodium salt".
5. APPLICABILITY DOMAIN
The substance was within the applicability domain. For more details, please refer to the QMRF attached in the section 13 with the title "Prediction of Skin sensitisation for Benzenesulfonic acid, 4-hydroxy-, monosodium salt".
6. ADEQUACY OF THE RESULT
The prediction supports the conclusion that the substance is not a skin sensitiser and thus no classification is required.
Data source
Reference
- Reference Type:
- other: OECD Toolbox Prediction
- Title:
- Prediction of Skin sensitisation for Benzenesulfonic acid, 4-hydroxy-, monosodium salt
- Author:
- NA
- Year:
- 2 021
- Bibliographic source:
- OECD Toolbox v 4.4.1
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6. May/July 2006
- GLP compliance:
- no
- Remarks:
- QSAR, hence not applicable
Test material
- Reference substance name:
- Sodium 4-hydroxybenzenesulphonate
- EC Number:
- 212-550-0
- EC Name:
- Sodium 4-hydroxybenzenesulphonate
- Cas Number:
- 825-90-1
- Molecular formula:
- C6H6O4S.Na
- IUPAC Name:
- sodium 4-hydroxybenzenesulphonate
- Test material form:
- solid
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- other: Skin sensitisation
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
All the alerts related to skin sensitisation came out negative. Also the automated workflow predicted the substance to be negative in the Guinea pig maximisation test using read across.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Sodium 4-hydroxybenzenesulfonate was predicted to be not a skin sensitiser.
- Executive summary:
An attempt was made to predict the skin sensitisation potential of sodium 4 -hydroxybenzenesulfonate using the OECD Toolbox v 4.4.1. In first step, the profiling schemes related to the skin sensitisation were run. In the second step, the auomated workflow for skin sensitisation for GPMT was run. All the alerts related to skin sensitisation came out negative. Also the automated workflow predicted the substance to be negative in the Guinea pig maximisation test using read-across.
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