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Description of key information

LD50 values of 80 -150 mg/kg bw were obtained from acute oral toxicity studies performed in rats. Classification as acute toxicity category 3 is applicable according to the CLP criteria along with hazard statement H301 : toxic if swallowed. The determination of acute inhalation and acute dermal toxicity was performed by calculation using the available acute oral toxicity and kinetic data. Classification as acute toxicity category 4 is applicable according to the CLP criteria along with hazard statement H332 : harmful if inhaled. The substance is not classified regarding acute dermal toxicity according to the CLP criteria.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
80 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
Value:
1 130 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
14 032 mg/kg bw

Additional information

Justification for classification or non-classification

LD50 values of 80 -150 mg/kg bw were obtained from acute oral toxicity studies performed in rats. Classification as acute toxicity category 3 is applicable according to the CLP criteria along with hazard statement H301 : toxic if swallowed. The determination of acute inhalation and acute dermal toxicity was performed by calculation using the available acute oral toxicity and kinetic data. Classification as acute toxicity category 4 is applicable according to the CLP criteria along with hazard statement H332 : harmful if inhaled. The substance is not classified regarding acute dermal toxicity according to the CLP criteria.

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