Registration Dossier
Registration Dossier
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EC number: 298-995-1 | CAS number: 93841-25-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Hydroxyethyl-p-phenylenediamine sulfate was negative in the bacterial gene mutation test as well as in the in vitro gene mutation test in mammalian cells. Positive results were reported in the in vitro micronucleus test.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Genetic toxicity in vivo
Description of key information
The clastogenic effects found in vitro were not confirmed in an in vivo bone marrow micronucleus test. Hydroxyethyl-p-phenylenediamine sulfate can be considered to have no in vivo genotoxic potential.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Hydroxyethyl-p-phenylenediamine sulfate is not mutagenic.
Justification for classification or non-classification
Hydroxyethyl-p-phenylenediamine sulfate was negative in the bacterial gene mutation test as well as in the in vitro gene mutation test in mammalian cells. Positive results were reported in the in vitro micronucleus test. The clastogenic effects found in vitro were not confirmed in an in vivo bone marrow micronucleus test. Hydroxyethyl-p-phenylenediamine sulfate can be considered to have no in vivo genotoxic potential.
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