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Environmental fate & pathways

Biodegradation in water: screening tests

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Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
Deviations:
no
GLP compliance:
yes
Oxygen conditions:
aerobic
Inoculum or test system:
other: Bacterial seed (Polyseed)
Duration of test (contact time):
28 d
Initial conc.:
>= 15 - <= 21 mg/L
Based on:
test mat.
Parameter followed for biodegradation estimation:
O2 consumption
Reference substance:
acetic acid, sodium salt
Parameter:
% degradation (O2 consumption)
Value:
0
Sampling time:
0 d
Parameter:
% degradation (O2 consumption)
Value:
-0.4
Sampling time:
7 d
Parameter:
% degradation (O2 consumption)
Value:
-0.1
Sampling time:
14 d
Parameter:
% degradation (O2 consumption)
Value:
-0.2
Sampling time:
21 d
Key result
Parameter:
% degradation (O2 consumption)
Value:
0.1
Sampling time:
28 d

Table 1: Oxygen Determinations over 28-Day Incubation Period         

Bottle Contents

Dissolved Oxygen (mg/L)

Day 0

Day 7

Day 14

Day 21

Day 28

Test Control

7.7

7.3

7.3

7.0

6.9

7.7

7.4

6.9

7.1

6.9

Bottle Contents

Dissolved Oxygen (mg/L)

Day 0

Day 7

Day 14

Day 21

Day 28

Test Substance:

PCP

7.7

7.6

7.1

7.3

7.0

7.7

7.6

7.2

7.1

6.8

Procedure Control:

Sodium Acetate

7.7

3.2

3.2

3.0

2.6

7.7

3.6

3.1

3.0

3.0

Toxicity Control: Sodium Acetate and PCP

7.7

3.5

3.6

3.0

3.7

Table 2: Kinetics for test substance

Day

% Dmean of
PCP

% Dmean of
Reference Substance

0

0.0

0.0

7

-0.4

72.0

14

-0.1

72.0

21

-0.2

74.0

28

+0.1

75.0
Validity criteria fulfilled:
yes
Interpretation of results:
under test conditions no biodegradation observed
Conclusions:
Under the conditions of this study, p-Cumylphenol was not readily biodegradable.
Executive summary:

The biodegradation potential of p-Cumylphenol was investigated under aerobic conditions over 28 days in a GLP-compliant study performed in accordance with OECD Test Guideline 301 D.

Degradation observed during the 28 day study was less than 1 %. Therefore, under the conditions of this study, p-Cumylphenol was not readily biodegradable.

Description of key information

p-Cumylphenol was not readily biodegradable.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

The biodegradation potential of p-Cumylphenol was investigated under aerobic conditions over 28 days in a GLP-compliant study performed in accordance with OECD Test Guideline 301 D (Guterson, 2001). Degradation observed during the 28 day study was less than 1 %. Therefore, under the conditions of this study, p-Cumylphenol was not readily biodegradable. In a 301B study, p-Cumylphenol did meet the criteria for being readily biodegradable. However, the results are inconsistent with other study results and results from similar substances.