Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 920-008-6
CAS number: -
data is being read across from the source study that tested undecane and
dodecane based on analogue read across.
Chemicals placed on the skin undergo
absorption into the stratum corneum and evaporation from the surface of
the skin. After absorption, the chemicals may be stored in deeper layers
of the stratum corneum or in the viable epidermis, or they may penetrate
into the dermis for eventual movement into the systemic circulation.
Some absorbed compound may also transfer back to the skin surface and
evaporate into the surrounding air.
The results are similar to in vitro studies
that use diffusion cells and pig skin. The tape-strip data showed
evidence of absorption of naphthalene, 1-methyl naphthalene, 2-methyl
naphthalene, decane, undecane, and dodecane, although decane seemed to
disappear faster from the surface of the stratum corneum. It is
estimated that aromatic components of JP-8 penetrate faster than the
aliphatic components. The flux of the aliphatic components is greater
than the flux of the aromatic components because the concentration of
the aliphatics in JP-8 is more than an order of magnitude greater than
the concentration of the aromatics. Our overall estimates of the
apparent Kp were smaller than the in vitro estimates.
Consequently, the study shows that
permeability coefficients estimated in vitro may overestimate the
internal dose of various components of JP-8. The results of the study
need to be interpreted with caution because in vitro systems do not
account for distribution and clearance mechanisms, i.e., processes such
as uptake into peripheral tissues, binding to proteins, metabolism, and
exhalation are not incorporated in diffusion-cell experiments.
The permeability coefficients (cm/h) of
aromatic and aliphatic hydrocarbons were determined to be: Naphthalene
5.3E−05; 1-Methyl naphthalene 2.9E−05; 2-Methyl naphthalene 3.2E−05;
Decane 6.5E−06; Undecane 4.5E−07; Dodecane 1.6E−06.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again