Registration Dossier
Registration Dossier
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EC number: 923-927-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Titantium salts and citrates are widley used in cosmetics and there is no indication of sensitising potential
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Example of published data on potential skin sensitisation of titanium salts
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
- Specific details on test material used for the study:
- Nano material used
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- male
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Remarks:
- Proportions not specified
- Concentration:
- 0.4, 4, 40 mg/ml suspension
- No. of animals per dose:
- Between 4 to 9 animals
- Positive control substance(s):
- other: Dintrobenzene
- Positive control results:
- Valid
- Parameter:
- SI
- Value:
- < 2
- Variability:
- Not specified
- Test group / Remarks:
- All groups
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Titantium salts and citrates are widley used in cosmetics and there is no indication of sensitising potential
Reference
Considered not to induce sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
