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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Dicarboxylic acid (C4–C6) dimethylester, mixture (dimethyl succinate, dimethyl adipate, dimethyl glutarate and their mixture)
Year:
2007
Bibliographic source:
The MAK-Collection for Occupational Health and Safety

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl succinate
EC Number:
203-419-9
EC Name:
Dimethyl succinate
Cas Number:
106-65-0
Molecular formula:
C6H10O4
IUPAC Name:
dimethyl succinate

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
No. of animals per sex per dose:
5 animals per sex

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 500 - < 5 000 mg/kg bw

Any other information on results incl. tables

500 mg/kg body weight: + 0/10; kidney changes (dilated renal pelvis, discoloration, tan nodules).

5000 mg/kg body weight: + 10/10; lethargy; rales (only 1 ♀); died animals: lungs: discoloration and oedema

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The substance has a LD50 which falls between 500 and 5000 mg/kg bw.