Registration Dossier
Registration Dossier
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EC number: 203-419-9 | CAS number: 106-65-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Dicarboxylic acid (C4–C6) dimethylester, mixture (dimethyl succinate, dimethyl adipate, dimethyl glutarate and their mixture)
- Year:
- 2 007
- Bibliographic source:
- The MAK-Collection for Occupational Health and Safety
Materials and methods
Test material
- Reference substance name:
- Dimethyl succinate
- EC Number:
- 203-419-9
- EC Name:
- Dimethyl succinate
- Cas Number:
- 106-65-0
- Molecular formula:
- C6H10O4
- IUPAC Name:
- dimethyl succinate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Amount / concentration applied:
- 0.1 mL
Results and discussion
In vivo
- Irritant / corrosive response data:
- Mild to slight irritation conjunctival redness, chemosis, tearing; iris changes, immediate washing prevented the iris changes.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Under the test conditions, eye irritation was observed; all effects were reversible within a week. Since no scores are actually stated, the study cannot be used for classification.
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