Registration Dossier
Registration Dossier
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EC number: 203-419-9 | CAS number: 106-65-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
The substance was not toxic to the fertility.
Link to relevant study records
- Endpoint:
- fertility, other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 90 days exposure
- Dose / conc.:
- 400 mg/m³ air
- Conclusions:
- Under the test conditions, no adverse substance-related effects on the reproductive organs were observed.
Reference
No adverse, substance-related effects on the reproductive organs were observed. Changes in individual hormone parameters and increased epididymal sperm counts were evaluated by the authors as unclear or as not assignable due to the high variability of the data and the relatively low number of animals/group and sex.
Effects on developmental toxicity
Description of key information
No data available.
Justification for classification or non-classification
Data available are deemed to be inconclusive to assess the classification in accordance with CLP Regulation.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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