Registration Dossier
Registration Dossier
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EC number: 203-419-9 | CAS number: 106-65-0
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- In vivo micronucleus tests in bone marrow erythrocytes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Dicarboxylic acid (C4–C6) dimethylester, mixture (dimethyl succinate, dimethyl adipate, dimethyl glutarate and their mixture)
- Year:
- 2 007
- Bibliographic source:
- The MAK-Collection for Occupational Health and Safety
Materials and methods
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- Dimethyl succinate
- EC Number:
- 203-419-9
- EC Name:
- Dimethyl succinate
- Cas Number:
- 106-65-0
- Molecular formula:
- C6H10O4
- IUPAC Name:
- dimethyl succinate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 3 days
Doses / concentrationsopen allclose all
- Dose / conc.:
- 312.5 mg/kg bw/day
- Dose / conc.:
- 625 mg/kg bw/day
- Dose / conc.:
- 1 250 mg/kg bw/day
- No. of animals per sex per dose:
- 5 males per dose
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Additional information on results:
- no information on PCE/NCE
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions, the substance was not genotoxic.
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