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EC number: 220-260-0 | CAS number: 2691-41-0
Preliminary tests indicated that the test substance should be non-irritant at a concentration of 60% w/v in paraffin oil on adjuvant pre-treated guinea pigs when applied to the shaved flank under occlusion.
The test substance did not elicit positive responses in the test group after challenge of the 25 guinea pigs by topical application.
The test substance was tested at the challenge phase on 10 guinea pigs which were Adjuvant pre-treated only.
None of these irritancy control group animals reacted positively to this topical application, so supporting the dose ranging results that at a concentration of 60% w/v in paraffin oil this test material would be non-irritant.
The skin sensitisation potential of HMX was investigated in a key study carried out by Inveresk Research Inernational Ltd on behalf of the U.S. Army Medical Research and Development Command. A guinea pig maximisation test was carried out using female albino guinea pigs of the Dunkin-Hartley strain. Groups of 25 guinea pigs were tested with HMX and a positive control substance (p-Phenylenediamine). The induction phase started with an intradermal exposure to HMX and HMX plus adjuvant. Six days after this exposure, an epidermal exposure to HMX was performed. An epicutaneous challenge was then performed at day 21. No indication of sensitisation was obtained.
A supporting study was available (McNamara et al, 1974). Topical or intradermal application of HMX in the solvents (DMSO, cyclohexanone and acetone) 3 days a week for 3 weeks, followed 2 weeks later by topical or intradermal challenge, gave no evidence of sensitisation.
A Magnusson-Kligman maximisation test in guinea pigs was carried out with HMX. Results were negative. Therefore HMX is not classified as a skin sensitiser.
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