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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2009
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: This is a recent guideline study under GLP, but only an English summary of the Chinese report is available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Guideline for testing of Chemicals 2004, No 402, China.
Deviations:
not specified
Principles of method if other than guideline:
The method used resembles the OECD 402 method.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-iminobis[4,6-diamino-1,3,5-triazine]
EC Number:
222-695-1
EC Name:
2,2'-iminobis[4,6-diamino-1,3,5-triazine]
Cas Number:
3576-88-3
Molecular formula:
C6H9N11
IUPAC Name:
2-N-(diamino-1,3,5-triazin-2-yl)-1,3,5-triazine-2,4,6-triamine

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
petrolatum
Details on dermal exposure:
The sample was fixed by vaseline, then the skin was isolated by covering a box for 24 h.
Duration of exposure:
24 h.
Doses:
2500 mg/kg bw.
No. of animals per sex per dose:
5 m + 5 f.
Control animals:
yes
Statistics:
Performed.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Based on:
test mat.
Mortality:
No.
Body weight:
No significant differences.
Gross pathology:
No significant gross lesions were observed.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 was greater than 2500 mg/kg bw.
Executive summary:

5 male + 5 female rats were dosed with 2500 mg/kg bw dermally and observed for 14 days. A control group was used too.

No significant toxic signs were observed and no abnormalities were detected at necropsy. The LD50 was greater than 2500 mg/kg bw.