Registration Dossier
Registration Dossier
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EC number: 294-436-0 | CAS number: 91722-33-7 A complex combination of organic compounds separated after condensation of the vapors from the destructive distillation of wood.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21.01.2014 - 06.02.2014
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Tar, wood
- EC Number:
- 294-436-0
- EC Name:
- Tar, wood
- Cas Number:
- 91722-33-7
- Molecular formula:
- not applicable
- IUPAC Name:
- Tar, wood
- Test material form:
- liquid: viscous
- Details on test material:
- Test item: Tar wood CAS No.: 91722-33-7 Batch No.: 18092013 Appearance: viscous Colour: brown Purity: 100 % mixture Expiry date: December 31, 2015 Storage: room temperature (15-25 °C) Safety precautions: See SDB
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:(WI)BR rats
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 2000 mg/kg bw
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Clinical signs:
- other:
Any other information on results incl. tables
see study report for further information
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The method used, was not intended for the precise calculation of a precise LD50 value. The test item was ranked into classes of Globally Harmonized Classification System (GHS) described in the OECD Guideline No. 423.
- Executive summary:
An acute toxic class method was carried out involving a stepwise procedure with the use of 2000 mg/kg bw as the starting dose in three female rats. No animal died in the first step at 2000 mg/kg bw dose level, therefore treatment with 2000 mg/kg bw was repeated on further three female rats. No animal died in the second step, too, so the test was finished, the stopping criteria of Annex 2d of OECD Guideline No. 423 (presented in Appendix VII) was met. Animals were weighed, observed for lethality and toxic symptoms for 14 days after the treatment. Gross pathological examination was carried out on the 15th day after the treatment.
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