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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

Currently viewing:

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
GLP compliance:
yes
Type of assay:
mammalian erythrocyte micronucleus test

Test material

Constituent 1
Chemical structure
Reference substance name:
Tar, wood
EC Number:
294-436-0
EC Name:
Tar, wood
Cas Number:
91722-33-7
Molecular formula:
not applicable
IUPAC Name:
Tar, wood
Test material form:
liquid: viscous
Details on test material:
Test item: Tar wood CAS No.: 91722-33-7 Batch No.: 18092013 Appearance: viscous Colour: brown Purity: 100 % mixture Expiry date: December 31, 2015 Storage: room temperature Safety precautions: see SDB
Specific details on test material used for the study:
Name: Scansmoke R909
Batch No: 03/2004

Test animals

Species:
mouse
Strain:
NMRI
Details on species / strain selection:
Strain: CRL: NMRI BR mice
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
distilled water
Doses / concentrationsopen allclose all
Dose / conc.:
500 mg/kg diet
Dose / conc.:
1 000 mg/kg diet
Dose / conc.:
2 000 mg/kg diet
Control animals:
yes
Positive control(s):
Cyclophosphamide (ip. administration)

Results and discussion

Test results
Key result
Sex:
male/female
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Negative controls validity:
not examined
Positive controls validity:
valid

Applicant's summary and conclusion

Executive summary:

No increases in the frequency of micronucleated polychromated erythrocytes (MCPE) in male and female mice at either 24 or 48 hours after treatment compared to the vehicle control.

Considerable differences in the ratio of polychromatic and normochromatic erythrocytes were not found after the treatment.

Biologically significant depression of PCE:NCE ratio was not observed in the study. The positive control showed significantly increased MCPE numbers compared to the control.