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Short-term toxicity to aquatic invertebrates

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Description of key information

A short term toxicity study in Daphnia magna with the test substance was performed according to OECD guideline No. 202 and GLP principles. A flow-through system was used for exposure, analysis showed that measured concentrations were stable during the test period, ranging between 81 and 109% of the target concentration. The 48-h nominal EC50 value was 81 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
81 mg/L

Additional information

In a 48 h acute toxicity study, waterfleas (Daphnia magna) were exposed to the test substance at the following nominal concentrations:

- Range-finding test: 0.1, 1, 10 and 100 mg/L

- Final test: 0 (blank control), 0 (acetone control), 4.6, 10, 22, 46 and 100 mg/L

In the final test a flow-through system was used for exposure, and analysis showed that measured concentrations were stable during the test period, ranging between 81 and 109% of the target concentration. The 48-h nominal EC50 value was 81 mg/L (95% confidence interval between 62 and 130 mg/L).

All criteria for acceptability of the test were met and the present toxicity study is classified as reliable without restrictions according to the OECD guideline No. 202.