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EC number: 426-040-2 | CAS number: 25713-60-4 SR-245
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
PBT assessment is done only on the product since there are no degradation products. FR-245 is a hydrophobic molecule with molecular weight of 1067g/mol. The substance has an extremely low water solubility (< 1μg/l), and a high estimated logPow of 8.63. Accordingly, it seems very unlikely that the substance will be available for aquatic organisms through the water compartment.
The persistency of the substance was investigated and confirmed in simulation tests conducted in water sediment systems. The transformation of 14C- FR-245 was assessed in aerobic and anaerobic systems. The
DT50 calculated from the simulation studies exceeded 180 days under both conditions. The results of these studies indicate that FR-245 can be considered as very persistent (vP).
The bioaccumulation potential of FR-245 was assessed in a bioconcentration test. Fish were exposed to 0.5 mg/l which is much above the maximum level of water solubility of the substance. Therefore, no conclusive results could be obtained. Performing the study at the level of water solubility is quite impossible since the concentrations of the substance cannot be technically confirmed in water. However, results from the ADME study in rats show only minor absorption and retention of FR-245 in tissues (<0.2%), indicating virtually negligible uptake of the substance. These findings further support the conclusion that FR-245 will not be bioavailable and therefore will not bioaccumulate.
FR-245 did not show toxicity to aquatic organisms (fish, Daphnia and algae), although the tests were performed above the substance water solubility.
FR-245 did not show toxicity to the MidgeChironomus riparius, in a prolonged sediment toxicity test, NOEC greater than 1000 mg/Kg dry sediment.
FR-245 did not show toxicity to the survival and reproduction of the earthwormEsenia fetida, NOEC greater than 1000 mg/Kg dry soil.
The effect of FR-245 on the seedling emergence and growth of six species of terrestrial non-target higher plants was tested. Minimal toxicity effects were noted in all species tested (EC50 greater than 1000 mg/kg dry soil was achieved for all six species tested). The most sensitive species wasLycopersicon esculentumwith an NOEC 12.3mg/kg dry soil.
The substance is not a CMR and does not exhibit sub chronic toxicity systemic or target organ toxicity to human health.
Therefore, FR-245 does not fulfill the toxicity criterion.
The exposure assessment and risk characterization only needs to be performed if the substance is identified as a PBT, vPvB or meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EEC.
FR-245 is not PBT or vPvB and does not meet the criteria for classification as dangerous and therefore the exposure assessment and risk characterization sections of the chemical safety report are not required.
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