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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP and appropriate guidelines
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
not relevant
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine
EC Number:
426-040-2
EC Name:
2,4,6-tris(2,4,6-tribromophenoxy)-1,3,5-triazine
Cas Number:
25713-60-4
Molecular formula:
C 21 H 6 Br 9 N 3 O 3
IUPAC Name:
tris(2,4,6-tribromophenoxy)-1,3,5-triazine
Constituent 2
Reference substance name:
4260402
IUPAC Name:
4260402
Details on test material:
Identification SR-245
Description White powder
Batch 969066
Purity 100%
Test substance storage Room temperature in the dark
Stability under storage conditions Stable

Test animals

Species:
rat
Strain:
other: Cr1:(WI) BR (outbred,SPF-Quality)
Sex:
male/female
Details on test animals or test system and environmental conditions:
number of animals: 5 males and 5 females (females were nulliparous and non pregnant)
Age and body weight Young adult animals (approx. 7 weeks old) were selected. Body weight variation did not exceed +/- 20% of the sex means.
Identification Earmark
Husbandary:
Air conditioned room with approx 15 air changes/hr
Temp: 21 Deg C.
RH: 50%
Light: 12 hr artificial light 12 hr dark.
Accommodation: 5 animals per sex per cage.
Acclimatisation period was at least 5 days before start of the treatment
Diet Standard pelleted laboratory animal diet
Water Free access to tap water

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 1% Aqueous carboxymethyl cellulose
Details on oral exposure:
Oral gavage, using a stainless steel stomach tube
Fasting Food was withheld overnight prior to dosing until approx. 3-4 hours after administration of the test substance.
Frequency Single dose on day 1
Doses:
2000mg/kg (10 ml/kg) body weight
No. of animals per sex per dose:
5 males and 5 females (females were nulliparous and non pregnant)
Control animals:
no
Details on study design:
Mortality/Viability Twice daily
Body weights Days 1 (pre administration), 8 and 15
Clinical signs At periodic intervals on day of dosing (day 1) and once daily thereafter.until day 15.
Necropsy At the end of the observation period, all animals were sacrificed by asphyxiation using oxygen/carbon dioxide procedure and subjected to necropsy. Descriptions of all internal macroscopic abnormalities were recorded.
Statistics:
No statistical analysis was performed

Results and discussion

Preliminary study:
n/a
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Hunched posture was noted in all females and one male and piloerection in two females and one male, 2 hours after dosing.
Gross pathology:
Effects on organs:
No treatment-related macroscopic findings were observed.
Other findings:
n/a

Any other information on results incl. tables

See attached file on tables and figures

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 value of SR-245 in rats was established as exceeding 2000 mg/kg body weight.

Executive summary:

n/a