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Key value for chemical safety assessment

Additional information

3 in vitro studies were performed to assess the mutagenicity potential of FR-245:

Ames test: The substance was found to be not mutagenic in the Salmonella typhimurium reverse mutation assay.

Chromosome aberration: This substance was found to be not clastogenic in human lymphocytes.

In Virto mammalian gene mutation test: This substance was found to be not mutagenic in the mouse lymphoma L5178Y test system.

Further to the results of these studies it can be concluded that FR-245 is not mutagenic.

Short description of key information:
Reverse mutation assay Ämes test using Salmonella Typhimurium.
Chromosome aberration test in human lymphocytes.
In Vitro mammalian gene mutation test in mouse lymphoma test system.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The substance is not mutagenic.