Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Accidental release of titanium tetrachloride (TiCl4) in the context of major hazards-spill behaviour REACTPOOL
Author:
Kapias T, Griffiths RF
Year:
2005
Bibliographic source:
Journal of Hazardous Materials A119: 41-52
Reference Type:
publication
Title:
Epidemiologic Study of Lung Cancer Mortality in Workers Exposed to Titanium Tetrachloride
Author:
Fayerweather WE, Karns ME, Gilby PG, Chen JL
Year:
1992
Bibliographic source:
J. Occup. Med. 34(2): 164-169
Reference Type:
publication
Title:
Toxicological profile for titanium tetrachloride.
Author:
Agency for Toxic Substances and Disease Registry (ATSDR)
Year:
1997
Bibliographic source:
Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.

Materials and methods

Principles of method if other than guideline:
Rats were exposed to the test substance via inhalation. The LC50 (4h) was determined.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Titanium tetrachloride
EC Number:
231-441-9
EC Name:
Titanium tetrachloride
Cas Number:
7550-45-0
Molecular formula:
Cl4Ti
IUPAC Name:
titanium tetrachloride

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
not specified
Details on test animals or test system and environmental conditions:
unknown

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
head only
Vehicle:
other: unknown
Details on inhalation exposure:
unknown
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
unknown
No. of animals per sex per dose:
unknown
Control animals:
not specified
Details on study design:
unknown
Statistics:
unknown

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
0.46 mg/L air
Exp. duration:
4 h
Remarks on result:
other: Death was attributed to pulmonary edema (=> corrosive properties of TiCl4)
Mortality:
Death was attributed to pulmonary edema and occurred during exposures and up to one week post
exposure.
Clinical signs:
other: unknown
Body weight:
unknown
Gross pathology:
unknown

Applicant's summary and conclusion

Categories Display