Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-methylimidazole
EC Number:
210-484-7
EC Name:
1-methylimidazole
Cas Number:
616-47-7
Molecular formula:
C4H6N2
IUPAC Name:
1-methyl-1H-imidazole
Test material form:
liquid
Details on test material:
Substance name: 1-Methylimidazol (flüssig)
Substance number: XVI/41

Test animals

Species:
mouse
Strain:
other: Klsolegg-
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
The test substance was given as a 4 to 20% aqueous solution.
Doses:
200, 350, 400, 500, 640, 800 and 1600 mm3/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 447 mg/kg bw
Based on:
test mat.
Remarks on result:
other: (original value is 430 mm3/kg)
Mortality:
200 mm3/kg: no deaths after 7 days
320 mm3/kg: 2/10 animalses after 7 days
400 mm3/kg: 3/10 animals after 7 days
500 mm3/kg and up: all animals died after 7 days
Clinical signs:
Tonic cramps
Gross pathology:
No abnormal observations

Applicant's summary and conclusion