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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
not specified
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.17
Temp.:
20 °C
Remarks on result:
other: No pH reported
Details on results:
No data

No data

Conclusions:
Log P was determined equal to 1.17
Executive summary:

The determination of the partition coefficient (n-octanol/water; Poct) of TMTM was conducted in triplicate in accordance with OECD guideline 107. Log P was determined equal to 1.17

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
1.17
at the temperature of:
20 °C

Additional information

The determination of the partition coefficient (n-octanol/water) of TMTM was conducted in triplicate in accordance with OECD guideline 107. Log P was determined equal to 1.17.

As the substance falls within the applicability domain of the model, the use of QSAR to predict the Log Kow is an appropriate method and is suitable as a supporting study: the Log Kow for tetramethylthiuram monosulphide is calculated to be 0.75, which confirms the low value obtained with experimentation.