Registration Dossier
Registration Dossier
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EC number: 202-605-7 | CAS number: 97-74-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- "slight modfifications" is indicated
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Poecilia reticulata
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 5.3 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: (4.2 - 6.8)
- Reported statistics and error estimates:
- LC50 values and their 95% confidence intervals were calculated according to the Litchfield and Wilcoxon (1949) method.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The toxicity of tetramethylthiuram monosulphide to fish (poecilia reticulata) was assessed according to the OECD 203 guideline with semi-static conditions. LC50-96h was determined to be equal to 5.3 mg/L.
- Executive summary:
The toxicity of tetramethylthiuram monosulphide to fish (poecilia reticulata) was assessed according to the OECD 203 guideline with semi-static conditions. LC50-96h was determined to be equal to 5.3 mg/L.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.3 mg/L
Additional information
- LC50-96h: 5.3 mg/L (poecilia reticulata)
- LC50-96h: 2.3 mg/L (Salmo gairdneri)
- LC50-96h: 2.6 mg/L (Lepomis macrochirus)
The acute toxicity of tetramethylthiuram monosulphide to fish was assessed through several studies for which the followings LC50-96h were determined:
Studies performed with Salmo gairdneri and Lepomis macrochirus are mentioned in the HPV dossier dossier Thiuram, but as they belong to another company, the tox data are considered as supporting data. Thus, the "key data" is LC50-96h = 5.3 mg/L
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