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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
yes
Remarks:
"slight modfifications" is indicated
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Poecilia reticulata
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Reference substance (positive control):
not specified
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
5.3 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
mortality
Remarks on result:
other: (4.2 - 6.8)
Reported statistics and error estimates:
LC50 values and their 95% confidence intervals were calculated according to the Litchfield and Wilcoxon (1949) method.
Validity criteria fulfilled:
not specified
Conclusions:
The toxicity of tetramethylthiuram monosulphide to fish (poecilia reticulata) was assessed according to the OECD 203 guideline with semi-static conditions. LC50-96h was determined to be equal to 5.3 mg/L.
Executive summary:

The toxicity of tetramethylthiuram monosulphide to fish (poecilia reticulata) was assessed according to the OECD 203 guideline with semi-static conditions. LC50-96h was determined to be equal to 5.3 mg/L.

Description of key information

Key value for chemical safety assessment

LC50 for freshwater fish:
5.3 mg/L

Additional information

The acute toxicity of tetramethylthiuram monosulphide to fish was assessed through several studies for which the followings LC50-96h were determined:

  • LC50-96h: 5.3 mg/L (poecilia reticulata)
  • LC50-96h: 2.3 mg/L (Salmo gairdneri)
  • LC50-96h: 2.6 mg/L (Lepomis macrochirus)

Studies performed with Salmo gairdneri and Lepomis macrochirus are mentioned in the HPV dossier dossier Thiuram, but as they belong to another company, the tox data are considered as supporting data. Thus, the "key data" is LC50-96h = 5.3 mg/L