Registration Dossier
Registration Dossier
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EC number: 230-022-8 | CAS number: 6915-15-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Acute toxicity to fish: LC50 = > 100 mg/L; NOEC = 100 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Juvenile fish, D. rerio, were exposed to a single fumaric acid concentration of 100 mg/L in a semi-static acute toxicity test of 96 hours duration. The acidic nature of the tested substance resulted in a marked pH change (pH 4.3 - 5.0) which had, at the concentration tested, no influence on survival of the fish. The 96 -hour LC50 determined was >100 mg/L. The NOEC (no-observed effect concentration) was 100 mg/L.
Read across from fumaric acid to malic acid is considered valid and malic acid is concluded to have low toxicity to aquatic organisms. The rational for read across is that fumaric acid will metabolise in biological systems to malic acid. Fumaric acid is also slightly more fat soluble and is considered more likely to absorb to membranes and increase exposure to aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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