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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Data are available from in-vitro tests of both gene mutation and cytogenicity on both malic acid and fumaric acid. Read across between malic acid and fumaric acid is considered valid as metabolism of fumaric acid to malic acid occurs as a key part of the Krebbs Cycle

Short description of key information:
Genotoxicity in-vitro: Negative

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on results of the three different in vitro genetic toxicity studies, classification and labelling as genotoxic according to Directive 67/548/EEC (DSD) and to Regulation 1272/2008/EC (CLP) is not indicated.