Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Activated sludge respiration inhibition: >300 mg/L

Key value for chemical safety assessment

EC50 for microorganisms:
300 mg/L

Additional information

Activated sludge obtained from a sewage treatment plant was exposed in a 3 -hour respiration inhibition test to fumaric acid.The 3 -hour EC50 based on respiration inhibition was >300 mg fumaric acid/L.

Read across to fumaric acid is considered valid and malic acid is considered to exhibit similar low toxicity. The rational for read across is that fumaric acid will metabolise in biological systems to malic acid. Fumaric acid is also slightly more fat soluble and is considered more likely to absorb via membranes and increase transport.