Registration Dossier
Registration Dossier
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EC number: 230-279-6 | CAS number: 7005-47-2
Carcinogenicity
Administrative data
Description of key information
Based on all available information on DMAMP, the data demonstrate that the test substance seems highly unlikely to be carcinogenic and is not classifiable as carcinogen. Further testing is not required under Regulation (EC) 1907/2006, Annex XI, section 1.2.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on all available information on DMAMP, it is expected that DMAMP has no carcinogenic potential.The available data do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
Additional information
There are no animal data available on carcinogenicity or chronic toxicity of DMAMP. However, modelling of potential metabolites via the OECD QSAR toolbox v.2.0 (2010) did not predict relevant metabolites. Based on the chemical structure of DMAMP, no metabolism is expected. Therefore, it can be assumed that DMAMP will not show chemically reactive properties under in-vitro and in-vivo test conditions. Available studies via the oral and dermal route indicate that the biological properties of DMAMP are mainly governed by its intrinsic alkalinity.
DMAMP is not mutagenic or clastogenic in the available genetic toxicity studies and there is no evidence of neoplasia in repeated dose toxicity studies. Moreover, DMAMP bears no structural similarity to known carcinogens and has no functional groups associated with carcinogenicity. Therefore, it is concluded that DMAMP does not possess a carcinogenic potential.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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