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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

long-term toxicity to aquatic invertebrates
Data waiving:
exposure considerations
Justification for data waiving:

Description of key information

The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to aquatic invertebrates.

Key value for chemical safety assessment

Additional information

No experimental data evaluating the chronic toxicity of Bis(2-(2-butoxyethoxy)ethyl) adipate (CAS 141-17-3) to aquatic invertebrates are available. According to Regulation (EC) No 1907/2006, Annex IX, 9.1.5, long-term toxicity testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms.
This is not the case for Bis(2-(2-butoxyethoxy)ethyl) adipate since the environmental exposure assessment resulted in PEC/PNEC ratio of < 1. Moreover, the substance is not expected to be bioaccumulative and the PEC regional/local for the aquatic compartment is < 1/100th of the water solubility. According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance”, no risk for aquatic organisms is indicated (ECHA, 2017). Moreover, long-term exposure is not expected since the substance is readily biodegradable, and is thus expected to be removed from the aquatic environment within a short period of time. The available data investigating the effects of the substance to aquatic invertebrates clearly show that aquatic invertebrates are not the most sensitive trophic level organisms.
In conclusion, no chronic toxicity study is considered necessary to be conducted.