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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
sub-chronic toxicity: dermal
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
Adipic acid diesters category. See attached report.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-(2-butoxyethoxy)ethyl) adipate
EC Number:
205-465-5
EC Name:
Bis(2-(2-butoxyethoxy)ethyl) adipate
Cas Number:
141-17-3
Molecular formula:
C22H42O8
IUPAC Name:
bis(2-(2-butoxyethoxy)ethyl) adipate
Test material form:
other: liquid

Results and discussion

Effect levels

Key result
Dose descriptor:
NOAEL
Effect level:
> 2 000 mg/kg bw/day
Remarks on result:
not determinable due to adverse toxic effects at highest dose / concentration tested

Target system / organ toxicity

Key result
Critical effects observed:
no

Applicant's summary and conclusion

Conclusions:
According to the category read-across approach, no effects were observed in dermal repeated dose toxicy studies available among category members.