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EC number: 204-111-7
CAS number: 115-84-4
The authors concluded that based on weight gain, survival and the
absence of clinical signs, no signs of percutaneous absorption (leading
to systemic toxicity) were evident.
The acute dermal toxicity of 2 -Butyl-2 -ethyl-1,3 -propanediol (BEPD)
was determined in a limit test with 5 male and 5 female CD(SD)BR
VAF/Plus rats. The test substance was applied (after moistening with
distilled water) to the shaved skin of the rats, in a single dose of
2000 mg/kg bw. The test substance was held in place for 24 hours under
an occlusive dressing, the skin was washed following dressing removal.
There were no mortalities, and no abnormal clinical signs were noted
during 14 day observation period, and all rats gained weight. There were
no treatment-related findings at gross necropsy. The authors concluded
that based on weight gain, survival and the absence of clinical signs,
no signs of percutaneous absorption (leading to systemic toxicity) were
evident. Based on the results obtained in this study, the acute dermal LD50of
BEPD to rats is >2000 mg/kg bw.
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