Registration Dossier
Registration Dossier
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EC number: 202-774-7 | CAS number: 99-63-8
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Dueva LA et al.
- Year:
- 1 989
- Bibliographic source:
- Gig. Tr. Prof. Zabol., (11):50-52 (CA112:71843u)
Materials and methods
Test material
- Reference substance name:
- Isophthaloyl dichloride
- EC Number:
- 202-774-7
- EC Name:
- Isophthaloyl dichloride
- Cas Number:
- 99-63-8
- Molecular formula:
- C8H4Cl2O2
- IUPAC Name:
- benzene-1,3-dicarbonyl dichloride
Constituent 1
Test animals
- Species:
- guinea pig
Administration / exposure
- Route of administration:
- other: epi- or intracutaneous administration
Results and discussion
Results of examinations
- Details on results:
- The test substance induced allergic responses in guinea pigs after epi- or intracutaneous administration. The number of T- and B- lymphocytes of blood usually decreased and increased, respectively. Serum concentrations of albumins and globulins decreased and increased (or had an increasing tendency), respectively.
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