Registration Dossier

Toxicological information

Immunotoxicity

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Administrative data

Endpoint:
immunotoxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Dueva LA et al.
Year:
1989
Bibliographic source:
Gig. Tr. Prof. Zabol., (11):50-52 (CA112:71843u)

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
guinea pig

Administration / exposure

Route of administration:
other: epi- or intracutaneous administration

Results and discussion

Results of examinations

Details on results:
The test substance induced allergic responses in guinea pigs after epi- or intracutaneous administration. The number of T- and B- lymphocytes of blood usually decreased and increased, respectively. Serum concentrations of albumins and globulins decreased and increased (or had an increasing tendency), respectively.

Applicant's summary and conclusion