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EC number: 202-774-7 | CAS number: 99-63-8
Skin: no skin irritation was observed in rabbits at 34.5 mg/cm2; reliability = 2.
Eye: OECD 405; no eye irritation was observed in rabbits at 100 mg/eye; reliability = 2; [CAS# 100-21-0]
While the material is not classified as a corrosive based on experimental data provided, it is known that an association with water produces the products of hydrolysis (organic acid and HCl) which would be expected to be corrosive to the skin and eye. The submitter acknowledges that in reality, exposure to human skin and eyes would include moisture, leading to a corrosive condition with sufficient exposure time and is classified as Cat 1A for skin corrosion and Cat 1 for eye damage.
0/6 of the rabbits exhibited skin corrosion after 4, 24, and 48 hours.
The test substance was applied at a dosage of 34.5 mg/cm2to the shaved skin of six Albino rabbits. The test substance was applied to the clipped skin on the animal's back and covered with cotton gauze loosely wrapped with rubber sheeting. After 4 hrs, the rabbits were removed from the stocks, the wrappings were removed and skin reactions were evaluated. The test sites were then washed. Readings were again made at 24 and 48 hours after the initial application. None of the rabbits exhibited skin corrosion after 4, 24, and 48 hours.
Table 1. Individual rabbit data showing eye irritation scores. The scores given at the 48 and 72 hour and 7 day time points were the same, hence these scores have been given in one column.
48 hours, 72 hours, 7 days
Limited information is available regarding this study. 100 mg undiluted test substance was applied to the eyes of albino rabbits. One rabbit showed a stronger reaction than the others, but in all cases eyes had returned to normal within 48 hours. The average irritation score 1 hour after application was 9.0 (out of 110), and at 24 hours was 4.5 (out of 110). The author classified the test substance as non-irritating to rabbit eyes.
Data on the parent chemical itself has been shown to not be an irritant or corrosive in experimental animal studies. While the material is not classified as corrosive based on experimental data provided, it is known that an association with water produces the products of hydrolysis (organic acid and HCl) which would be expected to be corrosive to the skin and eye. The submitter acknowledges that in reality, exposure to human skin and eyes would include moisture, leading to a corrosive condition with sufficient exposure time. Therefore, the chemical warrants classification as corrosive to the skin and eye, Cat 1A (Causes severe skin burns and eye damage) for skin irritation and Cat 1 (Causes serious eye damage) for eye irritation according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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