Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-774-7 | CAS number: 99-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4 hours
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Department of Transportation, Hazardous Material Regulations, Title 49 CFR, Section 173.240(a)(1), December 31, 1973
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isophthaloyl dichloride
- EC Number:
- 202-774-7
- EC Name:
- Isophthaloyl dichloride
- Cas Number:
- 99-63-8
- Molecular formula:
- C8H4Cl2O2
- IUPAC Name:
- benzene-1,3-dicarbonyl dichloride
- Details on test material:
- - Name of test material (as cited in study report): Isophthaloyl Chloride.
- Other name: Meta-phthalic acid, dichloride.
- Physical state: Crystals ground in mortar before applying.
- Analytical purity: 99+%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2-3 kg
- Housing: FDA-type stocks.
Test system
- Type of coverage:
- other: applied to skin under gauze pad.
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 grams of the test substance was applied under 1.5 by 1.5 inch (14.5 cm2), 12-ply cotton gauze pads and the trunk of each rabbit was then loosely wrapped with rubber sheeting. The overall dose that was applied equated to 34.5 mg/cm2)
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4, 24, and 48 hours
- Number of animals:
- 6
- Details on study design:
- Animals were placed in an FDA-type stock. The test substance was applied to the clipped skin on the animal's back and covered with cotton gauze loosely wrapped with rubber sheeting. After 4 hrs, the rabbits were removed from the stocks, the wrappings were removed and skin reactions were evaluated. The test sites were then washed. Readings were again made at 24 and 48 hours after the initial application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Remarks:
- irritation read only at 24 and 48 hours
- Irritation parameter:
- edema score
- Basis:
- other: all animals
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not reported
- Irritant / corrosive response data:
- 0/6 rabbits exhibited skin corrosion.
- Other effects:
- N/A
Any other information on results incl. tables
0/6 of the rabbits exhibited skin corrosion after 4, 24, and 48 hours.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was deemed not corrosive based on the requirements of the Department of Transportation, Hazardous Material Regulations, Title 49 CFR, Section 173.240(a)(1), December 31, 1973.
- Executive summary:
The test substance was applied at a dosage of 34.5 mg/cm2to the shaved skin of six Albino rabbits. The test substance was applied to the clipped skin on the animal's back and covered with cotton gauze loosely wrapped with rubber sheeting. After 4 hrs, the rabbits were removed from the stocks, the wrappings were removed and skin reactions were evaluated. The test sites were then washed. Readings were again made at 24 and 48 hours after the initial application. None of the rabbits exhibited skin corrosion after 4, 24, and 48 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
