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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication does not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Excretion kinetics of the rubber anti-oxidant N-isopropyl-N'-phenyl-p-phenylenediamine
Author:
Scansetti G et al.
Year:
1987
Bibliographic source:
International Archives Occupational Environmental Health 59, 537-543

Materials and methods

Principles of method if other than guideline:
other: skin absorption study with human volunteer

Test material

Constituent 1
Chemical structure
Reference substance name:
N-isopropyl-N'-phenyl-p-phenylenediamine
EC Number:
202-969-7
EC Name:
N-isopropyl-N'-phenyl-p-phenylenediamine
Cas Number:
101-72-4
Molecular formula:
C15H18N2
IUPAC Name:
N1-phenyl-N4-(propan-2-yl)benzene-1,4-diamine

Test animals

Species:
human

Results and discussion

Percutaneous absorptionopen allclose all
Dose:
2g/10l
Remarks on result:
other: 90 min
Remarks:
No IPPD present in urine
Dose:
2g/10l
Remarks on result:
other: 3 h
Remarks:
100 µg/l IPPD in urine
Dose:
2g/10l
Remarks on result:
other: 5 h
Remarks:
350 µg/l IPPD in urine
Dose:
2g/10l
Remarks on result:
other: 10.5 h
Remarks:
570 µg/l IPPD in urine

Any other information on results incl. tables

After 105 h max. exctretion peak, the excretion began to drop, ahowing three consecutive slopes; excretion ceased 7 d after exposure.

Applicant's summary and conclusion