Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The key study was a skin sensitisation study conducted in accordance with OECD guideline 406 using a Magnusson and Kligman test (Török-Bathó, 2013). Tantalum pentoxide was tested negative for skin sensitisation in this study.

In a second sensitisation study tantalum pentoxide was tested for sensitizing properties in accordance with OECD guideline 429 using the mouse Local Lymph Node Assay (Hargitai, 2013). In this study a stimulation index greater than 3 was obtained at the mid-concentration of 25 % but not at 50 % or 10 %. As no dose response occurred tantalum pentoxide can be considered as potentially not sensitizing, but the result from this study need to be verified.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

In accordance with criteria for classification for skin sensitisation of Regulation (EC) No. 1272/2008 and Directive 67/548/EEC , the test material did not elicit a response in the Maximisation assay and therefore does not meet the criteria for classification as a skin sensitiser.