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EC number: 227-177-9 | CAS number: 5698-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, guidline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Magnesium acrylate
- EC Number:
- 227-177-9
- EC Name:
- Magnesium acrylate
- Cas Number:
- 5698-98-6
- Molecular formula:
- C3H4O2.1/2Mg
- IUPAC Name:
- magnesium diacrylate
- Test material form:
- other: liquid
- Details on test material:
- aqueous solution of magnesium acrylate, 46.41 %
density: 1.248 g/ml
purity (based on 100% magnesium acrylate): 99.7%
pH-value: 6.4
colour: brown,
storage: at room temperature in darkness
expiry date: 18. November 2012
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Janvier, F-53940 Le Genest St Isle, France
- Age at study initiation: 8 weeks
- Weight at study initiation: 190 - 203 g
- Fasting period before study: no
- Housing: by groups of three
- Diet: ad libitum
- Water: ad libitum
- Acclimatization: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30-70
- Air changes (per hr): 10 - 15 changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 46.41% magnesium acrylate solution in water (test item) was applied as supplied by the sponsor without any use of further vehicle.
- Amount of vehicle (if gavage): 3.526 ml/kg body weight corresponding to 4400 mg/kg body weight of pure test item based on the density of 1.248 g/ml - Doses:
- 2042 mg Magnesium acrylate/kg body weight corresponding to 4400 mg/kg b.w. of the test item as supplied by the sponsor (46.41% solution with a density of 1.248 g/ml)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily (clinical signs)
- Frequency of weighing: D0, 2, 7 and day 14
- Necropsy of survivors performed: yes
The study was performed in two steps. In the first and the second step of the study, the test item was administered by stomach tube under a volume of 3.526 ml/kg body weight (corresponding to 4400 mg/kg b.w. of the test item as supplied by the sponsor (Density 1.248 g/ml)) using a suitable graduated syringe fitted with an metal canula.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 042 mg/kg bw
- Based on:
- act. ingr.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 4 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 46.61 % magnesium acrylate aqueous solution
- Mortality:
- no mortality occcured during the study
- Clinical signs:
- other: no clinical signs ofserved
- Gross pathology:
- no abnormal findings
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The LD 50 of Magnesium acrylate in a 46.41% test item solution is higher than 2000 mg Magnesium acrylate/kg body weight after oral administration by gavage in the rat.
- Executive summary:
A magnesium acrylate solution in water, 46.41 %, was administered to 2 groups of 3 female Sprague-Dawley rats by stomach tube. After repeated administration of 2042 mg/kg b.w. in 3.526 ml/kg b.w. no clinical signs and no mortality were observed.
After administration the body weight gain in both groups was still positive. The dissection of the animals at the end of the study revealed no macroscopic changes.
According to the results of this study the LD50 of Magnesium acrylate is higher than 2000 mg/kg b.w. and higher than 4400 mg/kg b.w. for Magnesium acrylate aqueous solution (46.41% solid content).
According to the criteria for classification, packing and labelling of dangerous substances and preparations in accordance with the EEC Directives 67/548, 2001/59 and 1999/45, the test item Magnesium acrylate solution must not be classified.
No symbol or risk phrase is required.
In accordance with the Regulation EC No. 1272/2008 on classification , labelling and packing of substances and mixtures, the test item must not be classified. No signal word or hazard statement is required.
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